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1

Expression of Insulin in Yeast: The Importance of Molecular Adaptation for Secretion and Conversion

Kjeldsen, Thomas, Balschmidt, Per, Diers, Ivan, Hach, Morten, Kaarsholm, Niels C., Ludvigsen, Svend

Journal:

Biotechnology and Genetic Engineering Reviews

Year:

2001

Language:

english

File:

PDF, 2.54 MB

english, 2001

2

Spectroscopic evidence for preexisting T- and R-state insulin hexamer conformations

Choi, Wonjae E., Borchardt, Dan, Kaarsholm, Niels C., Brzovic, Peter S., Dunn, Michael F.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 1.15 MB

english, 1996

3

Raman signatures of ligand binding and allosteric conformation change in hexameric insulin

Davide Ferrari, James R. Diers, David F. Bocian, Niels C. Kaarsholm, Michael F. Dunn

Journal:

Year:

2001

Language:

english

File:

PDF, 693 KB

english, 2001

4

Physicochemical characterisation of the two active site mutants Trp52→Phe and Asp55→Val of glucoamylase from Aspergillus niger

Trine Christensen, Torben P Frandsen, Niels C Kaarsholm, Birte Svensson, Bent W Sigurskjold

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2002

Language:

english

File:

PDF, 231 KB

english, 2002

5

Ligand Binding to Wild-type and E-B13Q Mutant Insulins: A Three-state Allosteric Model System Showing Half-site Reactivity

Curtis R. Bloom, Wonjae E. Choi, Peter S. Brzovic, Julie J. Ha Sheng-Tung Huang, Niels C. Kaarsholm, Michael F. Dunn

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 536 KB

english, 1995

6

A structural switch in a mutant insulin exposes key residues for receptor binding

Svend Ludvigsen, Helle B. Olsen, Niels C. Kaarsholm

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 641 KB

english, 1998

7

The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix

Helle B. Olsen, Svend Ludvigsen, Niels C. Kaarsholm

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 1.13 MB

english, 1998

8

Ionization behavior of native and mutant insulins: pK perturbation of B13-Glu in aggregated species

Niels C. Kaarsholm, Svend Havelund, Philip Hougaard

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 812 KB

english, 1990

9

Ligand-induced conformational change in the minimized insulin receptor

Morten Schlein, Svend Havelund, Claus Kristensen, Michael F. Dunn, Niels C. Kaarsholm

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 246 KB

english, 2000

10

Properties of Small Molecules Affecting Insulin Receptor Function

Schlein, Morten, Ludvigsen, Svend, Olsen, Helle B., Andersen, Asser S., Danielsen, Gillian M., Kaarsholm, Niels C.

Journal:

Year:

2001

Language:

english

File:

PDF, 306 KB

english, 2001

11

Sequence-specific 1H-NMR assignments for the aromatic region of several biologically active, monomeric insulins including native human insulin

Melinda Roy, Robert W.-K. Lee, Niels C. Kaarsholm, Henning Thøgersen, Jens Brange, Michael F. Dunn

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1990

Language:

english

File:

PDF, 913 KB

english, 1990

12

Structural signatures of the complex formed between 3-nitro-4-hydroxybenzoate and the Zn(II)-substituted R6 insulin hexamer

Helle Birk Olsen, Melissa R. Leuenberger-Fisher, Webe Kadima, Dan Borchardt, Niels C. Kaarsholm, Michael F. Dunn

Journal:

Protein Science

Year:

2003

Language:

english

File:

PDF, 439 KB

english, 2003

13

Structural Effects of Protein Lipidation as Revealed by Lys B29 -myristoyl, des(B30) Insulin

Olsen, Helle B., Kaarsholm, Niels C.

Journal:

Year:

2000

Language:

english

File:

PDF, 256 KB

english, 2000

14

Engineering stability of the insulin monomer fold with application to the structure-activity relationship

Kaarsholm, Niels C., Norris, Kjeld, Joergensen, Rikke J., Mikkelsen, Joergen, Ludvigsen, Svend, Olsen, Ole H., Soerensen, Anders R., Havelund, Svend

Journal:

Year:

1993

Language:

english

File:

PDF, 1.24 MB

english, 1993

15

Solution Structure of an Engineered Insulin Monomer at Neutral pH †

Olsen, Helle B., Ludvigsen, Svend, Kaarsholm, Niels C.

Journal:

Year:

1996

Language:

english

File:

PDF, 585 KB

english, 1996

16

Comparison of the Allosteric Properties of the Co(II)- and Zn(II)-Substituted Insulin Hexamers †

Bloom, Curtis R., Wu, Nancy, Dunn, Alex, Kaarsholm, Niels C., Dunn, Michael F.

Journal:

Year:

1998

Language:

english

File:

PDF, 138 KB

english, 1998

17

Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin

Kaarsholm, Niels C., Ko, Hui Chong, Dunn, Michael F.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.13 MB

english, 1989

18

Structural Asymmetry and Half-Site Reactivity in the T to R Allosteric Transition of the Insulin Hexamer

Brzovic, Peter S., Choi, Wonjae E., Borchardt, Dan, Kaarsholm, Niels C., Dunn, Michael F.

Journal:

Year:

1994

Language:

english

File:

PDF, 2.41 MB

english, 1994

19

Effects of calcium ion on ternary complexes formed between 4-(2-pyridylazo)resorcinol and the two-zinc insulin hexamer

Kaarsholm, Niels C., Dunn, Michael F.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.02 MB

english, 1987

20

Characterization of the r-state insulin hexamer and its derivatives. The hexamer is stabilized by heterotropic ligand binding interactions

Brader, Mark L., Kaarsholm, Niels C., Lee, Robert W. K., Dunn, Michael F.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.82 MB

english, 1991

21

Absence in papaya peptidase A catalyzed hydrolyses of a pKa .apprx. 4 present in papain-catalyzed hydrolyses

Schack, Poul, Kaarsholm, Niels C.

Journal:

Year:

1984

Language:

english

File:

PDF, 626 KB

english, 1984

22

The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core

Soerensen, Poul, Winther, Jakob R., Kaarsholm, Niels C., Poulsen, Flemming M.

Journal:

Year:

1993

Language:

english

File:

PDF, 741 KB

english, 1993

23

Half-Site Reactivity, Negative Cooperativity, and Positive Cooperativity: Quantitative Considerations of a Plausible Model †

Bloom, Curtis R., Kaarsholm, Niels C., Ha, Julie, Dunn, Michael F.

Journal:

Year:

1997

Language:

english

File:

PDF, 154 KB

english, 1997

24

Mechanisms of Stabilization of the Insulin Hexamer through Allosteric Ligand Interactions

Rahuel-Clermont, Sophie, French, Cherie A., Chou, Connie I., Kaarsholm, Niels C., Dunn, Michael F.

Journal:

Year:

1997

File:

PDF, 12 KB

1997

25

High-Resolution Structure of an Engineered Biologically Potent Insulin Monomer, B16 Tyr .fwdarw. His, As Determined by Nuclear Magnetic Resonance Spectroscopy

Ludvigsen, Svend, Roy, Melinda, Thoegersen, Henning, Kaarsholm, Niels C.

Journal:

Year:

1994

Language:

english

File:

PDF, 3.18 MB

english, 1994

26

Allosteric transition of the insulin hexamer is modulated by homotropic and heterotropic interactions

Choi, Wonjae E., Brader, Mark L., Aguilar, Valentin, Kaarsholm, Niels C., Dunn, Michael F.

Journal:

Year:

1993

Language:

english

File:

PDF, 1.51 MB

english, 1993

27

Mechanisms of Stabilization of the Insulin Hexamer through Allosteric Ligand Interactions †

Rahuel-Clermont, Sophie, French, Cherie A., Kaarsholm, Niels C., Dunn, Michael F.

Journal:

Year:

1997

Language:

english

File:

PDF, 208 KB

english, 1997

28

Binding of 2,6- and 2,7-Dihydroxynaphthalene to Wild-Type and E-B13Q Insulins: Dynamic, Equilibrium, and Molecular Modeling Investigations †

Bloom, Curtis R., Heymann, Robert, Kaarsholm, Niels C., Dunn, Michael F.

Journal:

Year:

1997

Language:

english

File:

PDF, 823 KB

english, 1997

29

Targeted purification development enabled by computational biophysical modeling

Insaidoo, Francis K., Rauscher, Michael A., Smithline, Shepard J., Kaarsholm, Niels C., Feuston, Bradley P., Ortigosa, Allison D., Linden, Thomas O., Roush, David J.

Journal:

Biotechnology Progress

Year:

2015

Language:

english

File:

PDF, 600 KB

english, 2015

30

DISCOVERY AND PRELIMINARY CHARACTERIZATION OF A NEW PROTEOLYTIC ACTIVITY IN DRIED PAPAYA LATEX EXTRACT

Kaarsholm, Niels Christian, Schack, Poul

Journal:

Biochemical Society Transactions

Year:

1981

Language:

english

File:

PDF, 137 KB

english, 1981

31

IMPROVED RESOLUTION IN THE SEPARATION OF THE PROTEINS IN DRIED PAPAYA LATEX EXTRACT, AND DEFINITION OF STANDARD CONDITIONS FOR ION EXCHANGE CHROMATOGRAPHIC IDENTIFICATION OF THE COMPONENTS

Schack, Poul, Dinesen, Dines Kåre, Kaarsholm, Niels Christian

Journal:

Biochemical Society Transactions

Year:

1981

Language:

english

File:

PDF, 119 KB

english, 1981

32

Engineering Glucose Responsiveness Into Insulin

Kaarsholm, Niels C., Lin, Songnian, Yan, Lin, Kelly, Theresa, van Heek, Margaret, Mu, James, Wu, Margaret, Dai, Ge, Cui, Yan, Zhu, Yonghua, Carballo-Jane, Ester, Reddy, Vijay, Zafian, Peter, Huo, Pei,

Journal:

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

33

Superior Glycemic Control with a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Moore, Mary Courtney, Kelley, David E., Camacho, Raul C., Zafian, Peter, Ye, Tian, Lin, Songnian, Kaarsholm, Niels C., Nargund, Ravi, Kelly, Terri M., Van Heek, Margaret, Previs, Stephen F., Moyes, Ch

Journal:

Year:

2018

Language:

english

File:

PDF, 889 KB

english, 2018

34

Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299–308

Kaarsholm, Niels C., Lin, Songnian, Yan, Lin, Kelly, Theresa, van Heek, Margaret, Mu, James, Wu, Margaret, Dai, Ge, Cui, Yan, Zhu, Yonghua, Carballo-Jane, Ester, Reddy, Vijay, Zafian, Peter, Huo, Pei,

Journal:

Year:

2018

Language:

english

File:

PDF, 435 KB

english, 2018

35

Spectroscopic characterization of insulin and small molecule ligand binding to the insulin receptor

Schlein, Morten, Ludvigsen, Svend, Olsen, Helle B., Dunn, Michael F., Kaarsholm, Niels C.

Journal:

Spectroscopy / An International Journal

Year:

2002

Language:

english

File:

PDF, 1.33 MB

english, 2002

36

Clinical Evaluation of MK-2640: An Insulin Analog with Glucose-Responsive Properties

Krug, Alexander W., Visser, Sandra A.G., Tsai, Kuenhi, Kandala, Bhargava, Fancourt, Craig, Thornton, Bob, Morrow, Linda, Kaarsholm, Niels C., Bernstein, Harold S., Aubrey Stoch, S., Crutchlow, Michael

Journal:

Clinical Pharmacology & Therapeutics

Year:

2018

Language:

english

File:

PDF, 314 KB

english, 2018

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